Kinetic Constants Determined from Membrane Transport Measurements: Carbonic Anhydrase Activity at High Concentrations
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چکیده
منابع مشابه
Dissociation constants for carbonic acid determined from field measurements
A number of workers have recently shown that the thermodynamic constants for the dissociation of carbonic acid in seawater of Mehrbach et al. are more reliable than measurements made on artificial seawater. These studies have largely been confined to looking at the internal consistency of measurements of total alkalinity (TA), total inorganic carbon dioxide (TCO2) and the fugacity of carbon dio...
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Most measurements of blood carbonic anhydrase activity recorded in the literature have been made by the method of Meldrum and Roughton (1) or some modification of it. These procedures are carried out in a cold water bath at 10” or below. This temperature is disadvantageous technically, and, moreover, affords no direct information as to the activity of the enzyme at mammalian body temperature; i...
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Logan, R. W., Crooks, S. M., Hutchison, J. H., and Kerr, M. M. (1973). Archives of Disease in Childhood, 48, 256. Blood carbonic anhydrase activity in the newborn. Erythrocyte carbonic anhydrase activity was measured in 7 adults, 12 mature newborn infants, 12 preterm low birthweight infants, 9 'dysmature' infants, 33 infants with the respiratory distress syndrome (RDS), and 5 infants who had re...
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Metastatic tumors are often hypoxic exhibiting a decrease in extracellular pH (~6.5) due to a metabolic transition described by the Warburg Effect. This shift in tumor cell metabolism alters the tumor milieu inducing tumor cell proliferation, angiogenesis, cell motility, invasiveness, and often resistance to common anti-cancer treatments; hence hindering treatment of aggressive cancers. As a re...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1974
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.71.12.4995